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The major source of ROS production appears to be located inside the mitochondrial electron transport chain where electrons can evade their path and react with oxygen [15]
Ex-4 treatment upregulates the expression of the proteins critical for mitochondrial biogenesis, including peroxisome proliferator-activated receptor- coactivator-1 (PGC-1), nuclear respiratory factor-1 (NRF-1), and transcription factor a, mitochondrial (Tfam)
It should be noted that the GLP-1R + DVC/AP neurons project to the lateral parabrachial nucleus (PBN), which is in close proximity to the LC
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